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Evaluation of free radical scavenging, antiinflammatory and wound healing effects of Nephelium lappaceum leaf extract

Nephelium lappaceum also known as Rambutan is a locally grown popular tropical fruit grown in these parts of Asia. 2,2-diphenyl-1-picrylhydrazyl (DPPH) model of in vitro free radical scavenging test was performed with leaf extracts. The extract was also tested on wound healing activity using mice ex...

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Main Authors: Subramanian, R., Marhain, N., Bhattacharjee, A., Ahmad, Syahida
Format: Article
Language:English
Published: Societa Italo-Latinoamericana di Etnomedicina 2018
Online Access:http://psasir.upm.edu.my/id/eprint/72634/1/Evaluation%20of%20free%20radical%20scavenging.pdf
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spelling oai:psasir.upm.edu.my:72634 http://psasir.upm.edu.my/id/eprint/72634/ Evaluation of free radical scavenging, antiinflammatory and wound healing effects of Nephelium lappaceum leaf extract Subramanian, R. Marhain, N. Bhattacharjee, A. Ahmad, Syahida Nephelium lappaceum also known as Rambutan is a locally grown popular tropical fruit grown in these parts of Asia. 2,2-diphenyl-1-picrylhydrazyl (DPPH) model of in vitro free radical scavenging test was performed with leaf extracts. The extract was also tested on wound healing activity using mice excision model. The anti-inflammatory effect was tested in mice using the formalin induced paw licking test model. In the DPPH test, Nephelium lappaceum leaf extract at all concentrations was found to cause significant free radical inhibition (p<0.05). All concentrations of Nephelium lappaceum leaf extract showed significantly (p<0.05) high wound contraction on Day 6. In the animal model of inflammation, all doses of Nephelium lappaceum showed reduced number of paw licking. In conclusion, Nephelium lappaceum leaf extract demonstrated in vitro free radical scavenging, anti-inflammatory and wound healing effects. Societa Italo-Latinoamericana di Etnomedicina 2018-08 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/72634/1/Evaluation%20of%20free%20radical%20scavenging.pdf Subramanian, R. and Marhain, N. and Bhattacharjee, A. and Ahmad, Syahida (2018) Evaluation of free radical scavenging, antiinflammatory and wound healing effects of Nephelium lappaceum leaf extract. PharmacologyOnline, 2. 93 - 100. ISSN 1827-8620 https://pharmacologyonline.silae.it/front/archives_2018_2
institution UPM IR
collection UPM IR
language English
description Nephelium lappaceum also known as Rambutan is a locally grown popular tropical fruit grown in these parts of Asia. 2,2-diphenyl-1-picrylhydrazyl (DPPH) model of in vitro free radical scavenging test was performed with leaf extracts. The extract was also tested on wound healing activity using mice excision model. The anti-inflammatory effect was tested in mice using the formalin induced paw licking test model. In the DPPH test, Nephelium lappaceum leaf extract at all concentrations was found to cause significant free radical inhibition (p<0.05). All concentrations of Nephelium lappaceum leaf extract showed significantly (p<0.05) high wound contraction on Day 6. In the animal model of inflammation, all doses of Nephelium lappaceum showed reduced number of paw licking. In conclusion, Nephelium lappaceum leaf extract demonstrated in vitro free radical scavenging, anti-inflammatory and wound healing effects.
format Article
author Subramanian, R.
Marhain, N.
Bhattacharjee, A.
Ahmad, Syahida
spellingShingle Subramanian, R.
Marhain, N.
Bhattacharjee, A.
Ahmad, Syahida
Evaluation of free radical scavenging, antiinflammatory and wound healing effects of Nephelium lappaceum leaf extract
author_facet Subramanian, R.
Marhain, N.
Bhattacharjee, A.
Ahmad, Syahida
author_sort Subramanian, R.
title Evaluation of free radical scavenging, antiinflammatory and wound healing effects of Nephelium lappaceum leaf extract
title_short Evaluation of free radical scavenging, antiinflammatory and wound healing effects of Nephelium lappaceum leaf extract
title_full Evaluation of free radical scavenging, antiinflammatory and wound healing effects of Nephelium lappaceum leaf extract
title_fullStr Evaluation of free radical scavenging, antiinflammatory and wound healing effects of Nephelium lappaceum leaf extract
title_full_unstemmed Evaluation of free radical scavenging, antiinflammatory and wound healing effects of Nephelium lappaceum leaf extract
title_sort evaluation of free radical scavenging, antiinflammatory and wound healing effects of nephelium lappaceum leaf extract
publisher Societa Italo-Latinoamericana di Etnomedicina
publishDate 2018
url http://psasir.upm.edu.my/id/eprint/72634/1/Evaluation%20of%20free%20radical%20scavenging.pdf
_version_ 1819299056997892096
score 13.4562235

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