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Jellyfish collagen hydrolysate-loaded niosome for topical application: formulation development, antioxidant and antibacterial activities

Vesicular carrier system, niosome, has become an attractive delivery system for active ingredients in cosmetics and pharmaceuticals. This study aims to prepare a niosome formulation containing collagen hydrolysate extracted from local jellyfish (Rhopilema hispidum) with promising antioxidant and ant...

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Main Authors: Ab Aziz, Noor Atikah, Salim, Norazlinaliza, Saari, Nazamid, Md. Yusoff, Fatimah, Zarei, Mohammad
Format: Article
Published: Universiti Malaysia Terengganu 2022
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id oai:psasir.upm.edu.my:102025
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spelling oai:psasir.upm.edu.my:102025 http://psasir.upm.edu.my/id/eprint/102025/ Jellyfish collagen hydrolysate-loaded niosome for topical application: formulation development, antioxidant and antibacterial activities Ab Aziz, Noor Atikah Salim, Norazlinaliza Saari, Nazamid Md. Yusoff, Fatimah Zarei, Mohammad Vesicular carrier system, niosome, has become an attractive delivery system for active ingredients in cosmetics and pharmaceuticals. This study aims to prepare a niosome formulation containing collagen hydrolysate extracted from local jellyfish (Rhopilema hispidum) with promising antioxidant and antibacterial properties. Niosomes, which are composed of a mixture of non-ionic surfactants, was prepared by using coacervation and sonication techniques optimized using a D-optimal mixture experimental design (MED) to obtain a small particle size. The particle size of the niosome obtained was 111.2 nm with a polydispersity index (PDI) value of 0.256 and a zeta potential value of −6.62 mV. Transmission Electron Microscopy (TEM) study showed the formation of spherical bilayer vesicle with a size correlating well with Zetasizer analysis. The stability of the niosome formulation was studied over a 60-day period, during which changes in particle size from 104.5 to 386.5 nm were observed. The results showed no phase separation or creaming. Niosome obtained from this study was shown to exhibit antioxidant (65.9% DPPH scavenging activity and 34.6% metal chelating activity) and exhibited inhibitory activity against Staphylococcus aureus (up to 98.8%). The optimized niosome might be suitable for topical application. Universiti Malaysia Terengganu 2022 Article PeerReviewed Ab Aziz, Noor Atikah and Salim, Norazlinaliza and Saari, Nazamid and Md. Yusoff, Fatimah and Zarei, Mohammad (2022) Jellyfish collagen hydrolysate-loaded niosome for topical application: formulation development, antioxidant and antibacterial activities. Journal of Sustainability Science and Management, 17 (2). pp. 1-17. ISSN 1823-8556; ESSN: 2672-7226 https://jssm.umt.edu.my/?page_id=4696 10.46754/jssm.2022.02.001
institution UPM IR
collection UPM IR
description Vesicular carrier system, niosome, has become an attractive delivery system for active ingredients in cosmetics and pharmaceuticals. This study aims to prepare a niosome formulation containing collagen hydrolysate extracted from local jellyfish (Rhopilema hispidum) with promising antioxidant and antibacterial properties. Niosomes, which are composed of a mixture of non-ionic surfactants, was prepared by using coacervation and sonication techniques optimized using a D-optimal mixture experimental design (MED) to obtain a small particle size. The particle size of the niosome obtained was 111.2 nm with a polydispersity index (PDI) value of 0.256 and a zeta potential value of −6.62 mV. Transmission Electron Microscopy (TEM) study showed the formation of spherical bilayer vesicle with a size correlating well with Zetasizer analysis. The stability of the niosome formulation was studied over a 60-day period, during which changes in particle size from 104.5 to 386.5 nm were observed. The results showed no phase separation or creaming. Niosome obtained from this study was shown to exhibit antioxidant (65.9% DPPH scavenging activity and 34.6% metal chelating activity) and exhibited inhibitory activity against Staphylococcus aureus (up to 98.8%). The optimized niosome might be suitable for topical application.
format Article
author Ab Aziz, Noor Atikah
Salim, Norazlinaliza
Saari, Nazamid
Md. Yusoff, Fatimah
Zarei, Mohammad
spellingShingle Ab Aziz, Noor Atikah
Salim, Norazlinaliza
Saari, Nazamid
Md. Yusoff, Fatimah
Zarei, Mohammad
Jellyfish collagen hydrolysate-loaded niosome for topical application: formulation development, antioxidant and antibacterial activities
author_facet Ab Aziz, Noor Atikah
Salim, Norazlinaliza
Saari, Nazamid
Md. Yusoff, Fatimah
Zarei, Mohammad
author_sort Ab Aziz, Noor Atikah
title Jellyfish collagen hydrolysate-loaded niosome for topical application: formulation development, antioxidant and antibacterial activities
title_short Jellyfish collagen hydrolysate-loaded niosome for topical application: formulation development, antioxidant and antibacterial activities
title_full Jellyfish collagen hydrolysate-loaded niosome for topical application: formulation development, antioxidant and antibacterial activities
title_fullStr Jellyfish collagen hydrolysate-loaded niosome for topical application: formulation development, antioxidant and antibacterial activities
title_full_unstemmed Jellyfish collagen hydrolysate-loaded niosome for topical application: formulation development, antioxidant and antibacterial activities
title_sort jellyfish collagen hydrolysate-loaded niosome for topical application: formulation development, antioxidant and antibacterial activities
publisher Universiti Malaysia Terengganu
publishDate 2022
_version_ 1819301317273714688
score 13.4562235

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